About Trizepatide

Hello. My name is Alex Miras.

I am professor of endocrinology at Alta University and consultant, endocrinologist in Beyond BMI, and I'm preparing this video to talk to you about Munjaro or tirzepatide, which is the latest addition in the medications that we have to treat the disease of obesity.

We're very excited that, tirzepatide is now available.

It is, the most effective medical treatment we have for obesity because at the highest doses used, it can cause a weight loss of approximately twenty two percent, which is a very large number, and, we expect we'll have major health benefits to people's health.

Why is the medication more effective than the ones that were used before or the ones that we are currently using?

It's because it doesn't just contain one, but it contains two appetite regulating hormones. Both of them are produced from our intestine when we eat, and they make us feel full.

Therefore, the company that makes Manjaro has now manufactured them into a single injection, which is done once a week. And by taking the medication, we artificially make your brain or we trick your brain to think that it is full.

Therefore, whatever you eat now is going to be reduced, and that's the what causes the weight loss. The medication doesn't work in any other way. That's what causes, the weight loss.

How much should we expect? Well, it depends on the dose. There are six doses of the medication. And to give you an idea of the effects, the five milligram dose causes a weight loss of 16% at one year of treatment.

The 20%, weight loss can be achieved with a ten milligram dose, and 22. 5% of weight loss can be achieved with a fifteen milligram dose of Munjaro. The medication, is an injection that people do themselves.

It's very easy to learn how to, use the pen, and, we're very happy to help you in this process. There are instructions in the in the box of the medications and various videos to show you how to inject.

Most people inject on their abdomen, once a week on the same day of the week. The time doesn't make a difference, but you do need to change the injection site every week.

The medication is very, very safe to take long term. But when people start taking it, they might experience some side effects. Those are in the vast majority of people transient.

The common ones are nausea, diarrhea, or constipation. But what people find is that after about eight to ten weeks of treatment, those side effects ease, and then they eventually either disappear or they become very manageable.

Of course, if you're having major issues with side effects, you need to let us know because there are things that we can do to help.

The two worst case scenarios in terms of side effects are the development of inflammation of the gallbladder, also called cholecystitis, or inflammation of the pancreas.

Now both of those are very, very uncommon, but you need to be able to recognize them.

What they cause is severe upper abdominal pain, in which case, you know there's something wrong. You need to seek medical assistance. And if the diagnosis is proven right, then what we do is stop the medication.

The good news is that even in the unlikely event that you do get those side effects, takes place, when we stop the medication, everything gets back to normal. There are no long term consequences.

Women of childbearing potential should not conceive when taking the medication, and women who are taking the oral contraceptive pills should take additional precautions, but only while we're increasing the doses.

After they have been on the stable dose, for a a while, at least four weeks or so, then, the, the oral contraceptive pill will continue to be as effective as it was previously.

There are six doses to the medication, two point five, five, seven point five, ten, twelve point five, and fifteen milligrams per week.

And we increase the dose every month until we reach either the fifteen milligram dose or the maximum tolerated dose, assuming, of course, that, this medication can be tolerated.

These are the key things that, I wanted you to know about the medication. We can have further discussions about this and about practicalities, when we meet, in the clinic.

I am very pleased that, the all of the regulatory authorities around the world, including the FDA and the European Medicines Agencies, have gone through all of the data, that demonstrate efficacy and safety of the medication.

They have approved it for use, and now it is available for us to use in everyday practice. Thank you for listening.